Prognostic utility of the Gleason grading system revisions

A summary of the changes to PCa grading from the original Gleason grading system to the latest prognostic grade grouping

THE 2005 AND 2014 MODIFIED GLEASON GRADING SYSTEMS One of the biggest changes to the Gleason grading system was the classification of Grades 1 and 2. Grade 1 tumors are generally benign, and Grade 2 tumors do not appear to differ from those classified as Grade 3. In 2005, Grade 2 was recommended to be used “rarely, if ever,” and in the 2014 modified Gleason grading system, grading started from ...

Patterns, art, and context: Donald Floyd Gleason and the development of the Gleason grading system.

The Gleason grading system is a standard method of assessing prostate cancer. Very little is known, however, about the person behind the system, Donald Floyd Gleason, MD, PhD. Our objective was to construct a biography of Gleason and show how his work advanced prostate cancer diagnosis. We reviewed Gleason's notes, letters, and publications with the Veteran's Administration Cooperative Urology ...

Prostate Cancer Grading: A Decade After the 2005 Modified Gleason Grading System.

Since 1966, when Donald Gleason, MD, first proposed grading prostate cancer based on its histologic architecture, there have been numerous changes in clinical and pathologic practices relating to prostate cancer. Patterns 1 and 2, comprising more than 30% of cases in the original publications by Gleason, are no longer reported on biopsy and are rarely diagnosed on radical prostatectomy. Many of...

Prostate Cancer Grading: A Decade After the 2005 Modified Gleason Grading System. - PubMed - NCBI

Abstract Since 1966, when Donald Gleason, MD, first proposed grading prostate cancer based on its histologic architecture, there have been numerous changes in clinical and pathologic practices relating to prostate cancer. Patterns 1 and 2, comprising more than 30% of cases in the original publications by Gleason, are no longer reported on biopsy and are rarely diagnosed on radical prostatectomy...

Gleason grading of prostate cancer. Contemporary approach.